More on ACNE ... Factors That Can Make ACNE Worse. Factors that can cause an Acne flare include: *Changing hormone levels in adolescent girls and adult women 2 to 7 days before their menstrual period starts *Friction caused by leaning on or rubbing the skin *Pressure from bike helmets, backpacks, or tight collars *Environmental irritants, such as pollution and high humidity *Squeezing or picking at blemishes *Hard scrubbing of the skin. - NIAMS
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